Research Scientist - RNAi Formulations 12-month Contract Onsite in Lexington, MA Must be able to work on a W2 Position Overview The Associate Research Scientist Contractor, RNAi Formulations, is a laboratory-based role focused on hands-on RNAi formulation development, biophysical and analytical characterization, and support of oligonucleotide delivery activities for injectable therapeutics. The role supports formulation development and characterization across preclinical RNAi and oligonucleotide projects and works closely with cross-functional partners specializing in non-viral delivery, formulation development, oligonucleotide chemistry, stability assays, PK, bioanalysis, CMC, and external collaborators. Requirements Support the development and characterization of preclinical RNAi and oligonucleotide formulations across portfolio and platform projects. Execute hands-on formulation preparation, biophysical characterization, analytical testing, and data analysis to support formulation selection and developability assessments. Establish and run screening assays for oligonucleotides in early discovery, including formulation performance, solubility, viscosity, osmolality, degradation, and stability assessments. Contribute to high-throughput and design-of-experiments approaches for formulation optimization, where applicable. Support long-term storage and stability evaluations for RNAi conjugates and oligonucleotide formulations. Maintain accurate experimental documentation and communicate findings through written summaries, reports, and internal presentations. Collaborate with internal stakeholders and external partners to support project deliverables and timelines. Identify technical gaps, propose practical solutions, and contribute to continuous improvement of formulation and characterization workflows. Work effectively in a multidisciplinary, fast-paced research environment with competing priorities and tight deadlines. Qualifications MS with approximately 3 years of relevant experience, or PhD with 1-3 years of relevant experience in pharmaceutical sciences, formulation sciences, chemical engineering, biophysics, analytical chemistry, oligonucleotide delivery, or a related discipline. Hands-on experience with oligonucleotide or antibodies/proteins formulation and characterization is strongly preferred. Experience developing or running analytical methods for solubility, viscosity, osmolality, aggregation, stability, or other developability assessments for complex oligonucleotide or antibody/protein formulations. Familiarity with automation, high-throughput screening, and DoE-based formulation optimization is an advantage. Strong experimental planning, documentation, data analysis, and problem-solving skills. Excellent verbal and written communication skills, with the ability to work effectively across disciplines and functions. Awareness of external trends and advances in RNA delivery, oligonucleotide therapeutics, and clinical translation is a plus. A track record of scientific contributions, publications, or conference presentations in relevant areas is a plus. #J-18808-Ljbffr
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